Nurse Xiao Zhang uses oral contraceptives to prevent pregnancy and has had no accidents for several years. At the beginning of this year, due to hospital reforms and self-study exams, she often had difficulty falling asleep at night, so she took diazepam to help her sleep. Recently, she discovered that she had stopped menstruating for more than two months and sometimes felt acidic in her stomach. Based on past experience, it looks very much like pregnancy. I went to the health department for an examination and was diagnosed with early pregnancy. She didn't believe it. The doctor asked her in detail about all aspects of her recent situation. Finally, the doctor told her for sure that her contraceptive failure was due to taking tranquillizers for a long time. This drug can block the enterohepatic circulation of oral contraceptives during their metabolism in the body, thereby affecting the efficacy of the drug.

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Oral contraceptive pills are simple and easy to use for contraception. According to reports, there are currently 50 to 60 million women in the world using this method for contraception. However, it is less well known that women taking birth control pills can still experience contraceptive failure if they take certain medications. Stability is one of them. This drug is an inducer of hepatic microsomal enzymes and can accelerate the metabolism of oral contraceptives in the body, thus reducing their contraceptive effect. Xiao Zhang took diazepam for a long time to help him sleep, which undoubtedly interfered with the effect of the contraceptive pill. In addition to diazepam, in recent years it has been discovered that there are many drugs that can interfere with the effects of oral contraceptives, such as phenytoin, phenobarbital, primidone, chlordiazepoxide, etc. In addition, long-term use of penicillin, erythromycin, chloramphenicol, and anti-tuberculosis drugs rifampin may also affect the contraceptive effect. The reason is that under normal circumstances, oral contraceptives release a hydrolytic enzyme by intestinal bacteria and are repeatedly absorbed in the enterohepatic circulation. Once this enterohepatic circulation is blocked, contraceptive failure may occur.

Therefore, if women of childbearing age are taking oral contraceptives and need to take other medicines for a long time due to illness, they should explain their use of contraceptives to their doctors for reference. Or stop taking oral contraceptive pills and switch to other safer and more effective contraceptive methods.

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