For many couples who are infertile but want to have children, in vitro fertilization is the most common method. However, two research reports on IVF published in the New England Journal of Medicine on the 7th pointed out that the risk of IVF babies being underweight or having major birth defects is twice that of babies born through normal conception.

Dr. Jennifer Kulinzczuk and her colleagues in Australia compared the birth records and birth defect records of 1,138 IVF babies and 4,000 babies born through normal conception and concluded that one in 10 of test-tube babies have birth defects. Kulinczuk said IVF babies are more likely to have birth defects than babies born from normal conception, including heart problems, mental retardation, harelips and deformed legs. The report shows that a survey of one-year-old children found that 9% of test-tube babies were diagnosed with major birth defects, while only 4% of children born from normal conception had birth defects.

Those women who undergo artificial insemination are generally older, and older women are more likely to give birth to babies with congenital defects. But Australian researchers say even taking this into account, IVF babies are more likely to have birth defects and be underweight than normal babies.

Currently, there are no reports on why IVF has such problems. But researchers point out that these problems may be caused by women's infertility or problems with the artificial insemination process itself, such as taking drugs to increase ovulation or protect the fetus, freezing and thawing embryos, or delaying egg fertilization.

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