Fang Hong, Department of Dermatology and Venereology, Zhejiang Medical Hospital No. 1 Hospital, said that in fact, neurosyphilis was common before liberation. Before the advent of penicillin, such patients were regarded as mental patients, accounting for 15%-30% of inpatients in mental hospitals. Fang Hong said that after Treponema pallidum enters the human body through contact infection, it multiplies in local lymph nodes and then enters the blood through lymphatic vessels, which can be said to be pervasive in all tissues of the body.

Everyone knows that syphilis is a sexually transmitted disease, but did you imagine that it would get into the brain? Not long ago, the Department of Dermatology and Venereology of the First Hospital of Zhejiang Medical University admitted three patients with neurosyphilis. The three patients suffered from varying degrees of headaches, numbness of hands and feet, irritability, gibbering and other neurological and mental problems. Fang Hong, director of the Department of Dermatology and Venereology of the First Hospital of Zhejiang Medical University, said that although the number of syphilis patients is increasing year by year, there used to be no more than five patients with neurosyphilis a year, but now three appear in a month, which is indeed relatively rare.

Fang Hong said that in fact, neurosyphilis was common before liberation. Before the advent of penicillin, such patients were regarded as mental patients, accounting for 15%-30% of inpatients in mental hospitals. This also shows that the brain is one of the parts that Treponema pallidum easily invades.

Fang Hong said that after Treponema pallidum enters the human body through contact infection, it multiplies in local lymph nodes and then enters the bloodstream through lymphatic vessels. It can be said to be pervasive in all tissues of the body. The onset of disease in the human body is roughly divided into three stages. Neurosyphilis mostly occurs in the late stage, mainly invading the central nervous system or cardiovascular system. If syphilis is highly toxic or the autoimmune system is low, it may also occur in the second stage.

Neurosyphilis generally has three manifestations. One is asymptomatic neurosyphilis. This type of patients accounts for 25% of neurosyphilis patients. As long as they can be treated in time, they can live like normal people. The other is asymptomatic neurosyphilis. One is interstitial neurosyphilis, which mainly invades the meninges and blood vessels and is an important cause of meningitis and stroke in young and middle-aged people. In addition to symptoms such as headache, vomiting, and numbness of the hands and feet, hemiplegia with impaired movement of the hands and feet is often present. The third type is parenchymal neurosyphilis, which mainly invades the brain parenchyma and is the result of severe late-stage syphilis. It is also called paralytic dementia and mainly manifests as mental disorder, dementia, and even cerebral palsy. The time from onset to death ranges from a few months to four to five years.

For this reason, Fang Hong suggested that if you have inexplicable headaches (not getting better for several months), numbness in your hands and feet, irritability, epilepsy, vision loss, etc., you should go to the hospital for a check-up in time and do a syphilis serum. Check to rule out syphilis.

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